Reversion of ‘Early Worsening’ of Diabetic Retinopathy by Deliberate Restoration of Poor Metabolic Control
- 20 August 2003
- journal article
- case report
- Published by S. Karger AG in Ophthalmologica
- Vol. 217 (5) , 373-377
- https://doi.org/10.1159/000071355
Abstract
Acutely lowering long-standing severe hyperglycaemia can trigger progression (‘early worsening’) of diabetic retinopathy, most likely by up-regulation of the circulating insulin-like growth factor 1 (IGF-1). This condition, also called ‘florid retinopathy’, rarely responds to standard laser coagulation treatment. In this retrospective report, 2 young patients with type 2 diabetes are described, in whom deliberate restoration of poor diabetes control reduced the serum IGF-1 levels and improved ‘early worsened’ diabetic retinopathy.Keywords
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