Isolation and characterization of a novel polyether antibiotic of the pyrrolether class,antibiotic X-14885A.

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Abstract
Antibiotic X-14885 A [produced by Streptomyces sp. X-14885] is a polyether antibiotic belonging to the class of these natural acid ionophores known as pyrrolethers. The structure of the antibiotic was elucidated by X-ray crystallographic analysis of the hydrated sodium salt, which crystallized as a tetramer containing 4 antibiotic and H2O molecules and 4 Na atoms. Antibiotic X-14885A differed from the most well-known member of the class A-23187 in 2 respects: the aromatic N-methylamino group present in the latter was replaced by a phenolic hydroxyl, and 1 of the 4 aliphatic methyls was replaced by a proton. Antibiotic X-14885A was active against gram-positive bacteria and the spirochete, Treponema hyodysenteriae.

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