THE CLINICAL INVESTIGATION OF AN IMPROVED CRYSTALLINE INSULIN

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Abstract
Clinicians have long felt the need for a slower and more prolonged action of insulin in diabetic patients to simulate the normally functioning pancreas in maintaining a more constant level of blood sugar. The rapidity with which insulin is absorbed and the short duration of its action often produce marked fluctuations in the blood sugar during the twenty-four hour period. Various modes of insulin administration have been tried, as well as various insulin compounds. This study deals with the observations in the clinical use of an improved crystalline insulin as to its rate of absorption and its duration of effect in diabetic patients. The material used was a solution of improved crystalline insulin developed by Dr. Melville Sahyun of Detroit.1A solution of the improved crystalline insulin cannot be distinguished in appearance from that of regular insulin. Our supply of this preparation was kept at room temperature for four

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