Mammalian Sterile 20–Like Kinases in Tumor Suppression: An Emerging Pathway
Open Access
- 1 July 2005
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 65 (13) , 5485-5487
- https://doi.org/10.1158/0008-5472.can-05-1453
Abstract
Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20–like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-1 kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf–mitogen-activated protein kinase signaling in cancer cells.Keywords
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