Allelic losses on chromosome band 11q13 in aldosterone‐producing adrenal tumors
- 1 January 1995
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 12 (1) , 73-75
- https://doi.org/10.1002/gcc.2870120114
Abstract
We examined loss of heterozygosity (LOH) in 14 aldosterone-producing adrenal tumors, with six linearly ordered restriction fragment length polymorphism (RFLP) markers that map within a 12-cM region containing the MEN 1 locus on 11q13. Among 11 tumors that were informative for at least one marker, five showed LOH at one or more loci, and two distinct regions of deletion were identified. The proximal region overlapped with the location of the MEN 1 locus previously predicted by linkage analyses in MEN 1 families and the commonly deleted region in hyperparathyroid tumors. This suggests that one of the genes associated with development of aldosterone-producing adrenal tumors may coincide with the MEN 1 locus, and that a second gene, distal to the MEN 1 locus, may also play a role in the development of this type of tumor.Keywords
This publication has 17 references indexed in Scilit:
- Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's diseaseNature, 1994
- A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinomaNature, 1994
- Mutations in the RET proto-oncogene are associated with MEN 2A and FMTCHuman Molecular Genetics, 1993
- Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2ANature, 1993
- Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers, including the MEN1 locusJournal of Clinical Endocrinology & Metabolism, 1992
- Primary aldosteronism: hypertension with a genetic basisThe Lancet, 1992
- A 14-Mb physical map of the region at chromosome 11q13 harboring the MEN 1 locus and the tumor amplicon regionGenomics, 1992
- CLINICAL AND PATHOLOGICAL DIVERSITY OF PRIMARY ALDOSTERONISM, INCLUDING A NEW FAMILIAL VARIETYClinical and Experimental Pharmacology and Physiology, 1991
- Primary aldosteronismJournal Of Hypertension, 1991
- Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11Genomics, 1989