Dichloromethylene Diphosphonate and Calcium and Phosphate Metabolism

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Abstract
To the Editor: A rapid and sustained lowering of urinary calcium excretion was the most striking change that Siris et al.1 observed in seven of eight patients with multiple myeloma who were treated with dichloromethylene diphosphonate. This effect was reversed after discontinuation of treatment. Lowering of hydroxyproline excretion was less marked but notable in six patients. Except in one patient, the decrease in calcium excretion was not accompanied by a lowering of total serum calcium. The data of Meunier et al.2 on urinary calcium excretion in patients with Paget's disease given dichloromethylene diphosphonate showed the same swift reversal, without a . . .