SOME EFFECTS OF CORTISONE ON METABOLIC DISTURBANCE ASSOCIATED WITH RENAL EDEMA

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Abstract
BRIEF edema were made last year.1 On three of these patients we have since completed detailed studies in the metabolic unit of the Mayo Clinic. Our results confirm many of those already reported with both cortisone and corticotropin (ACTH)2 therapy and add further information. Fortunately, we were able to study the metabolism of the same patient during two episodes of edema and treatment with cortisone. On both occasions we observed numerous chemical changes as the edema receded and the metabolism improved. The reactions of the patient were variable and confirmed a previous conception that each episode of edema may have unique features. Detailed facts, gained in this way, should lead to a clearer insight into the problem of the individual patient and the appropriate use of cortisone and other beneficial agents in the treatment of the edema of nephritis. Our patients sought medical care because of the presence

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