Intravenous administration of mannosylated cationic liposome/NFκB decoy complexes effectively prevent LPS‐induced cytokine production in a murine liver failure model
- 6 June 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (15) , 3706-3714
- https://doi.org/10.1016/j.febslet.2006.05.059
Abstract
The purpose of this study was to inhibit endotoxin induced cytokines production and liver injury by liver non‐parenchymal cell (NPC) selective delivery of nuclear factor κB (NFκB) decoy using mannosylated cationic liposomes (Man‐liposomes). In this study, we examined the distribution, inhibitory effect on cytokines production and ALT/AST of intravenously injected Man‐liposome/NFκB decoy complex. Man‐liposome/[32P] NFκB decoy complexes mostly accumulated in the liver, preferentially in NPC. In a murine lipopolysaccharide‐induced liver failure model, the production of tumor necrosis factor‐α (TNFα), IFNγ, IL1‐β, ALT and AST were effectively reduced by Man‐liposome complexes. However, cationic or galactosylated cationic liposome complexes could not inhibit TNFα production.Keywords
This publication has 28 references indexed in Scilit:
- Molecular therapy to inhibit NFκB activation by transcription factor decoy oligonucleotidesCurrent Opinion in Pharmacology, 2004
- Nuclear Factor κB Decoy Oligodeoxynucleotides Prevent Endotoxin–Induced Fatal Liver Failure in A Murine ModelHepatology, 2003
- The systemic inflammatory response syndrome in acute liver failureHepatology, 2000
- Activators and target genes of Rel/NF-κB transcription factorsOncogene, 1999
- Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependentProceedings of the National Academy of Sciences, 1998
- In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarctionNature Medicine, 1997
- Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B.The Journal of Experimental Medicine, 1996
- Function and Activation of NF-kappaB in the Immune SystemAnnual Review of Immunology, 1994
- Regulation of Gene Expression with Double-Stranded Phosphorothioate OligonucleotidesScience, 1990
- ENDOTOXINS AND DISEASE MECHANISMSAnnual Review of Medicine, 1987