Virulence of Strains of Herpes Simplex Virus for Mice

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Abstract
Twelve strains of herpes simplex virus, 11 recently isolated, and one, the laboratory HF strain were studied in mice. The incubation periods after intracerebral inoculation of a 10% suspension ranged from 30 to 96 hours. After intraperitoneal inoculation old mice resisted between 20-fold and at least 3000-fold more virus than did the young mice. Comparison of the results of intracerebral inoculation of young and old mice indicated that for 3 of the strains there was no difference; for 9 of them the old mice showed at least a 10-fold greater resistance of which 3 showed a 50-fold or greater difference and one more than 1000-fold difference. The differences in intracerebral susceptibility to fatal infection were caused by sublethal infection in older mice. When these were taken into account the differences were negligible.
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