Kinetics and dynamics of furosemide and slow-acting furosemide

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Abstract
Bioavailability and dynamics of a sustained-release preparation of furosemide (FR, 60 mg) were compared with those of a conventional tablet (F, 40 mg). The preparations were given to 12 healthy subjects in a study of crossover randomized design once daily for 1 wk. FR absorption was substantially delayed and the uptake of furosemide was .apprx. 75% of that from F, despite the larger dose administered. F induced a brief, intense diuresis and excretion of Na+, K+ and Cl-, both during short- and long-term administrations. There was no such peak after FR. Total diuretic and saluretic effects did not differ between the 2 preparations, despite the lower bioavailability of FR. This discrepancy might be caused by transient supamaximal urinary levels of furosemide after F, whereby not all of the drug can exert an effect.

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