The Determination of Thyroid Volume by Ultrasound and Its Relationship to Body Weight, Age, and Sex in Normal Subjects

Abstract
Using a precise and accurate ultrasonic scanning technique we have measured the volume of the thyroid gland in vivo in 271 healthy subjects (13–91 yr old). In these subjects the mean (±SD) thyroid volume was 18.6 ± 4.5 ml. A significant difference between males (19.6 ± 4.7 ml; n = 139) and females (17.5 ± 4.2 ml; n = 132) was found (P < 0.001). The thyroid volume was significantly correlated with both body weight and age, described by: Y = 1.97 + 0.21 · X1 + 0.06 · x2, where Y is the thyroid volume (milliliters), X1 is the body weight (kilograms), and X2 is the age (years). The influence of body weight on the thyroid volume was about 3 times that of age. The difference in thyroid gland volume between males and females was explained solely by a difference in body weight.

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