Congeners of the .beta. conformer of dopamine derived from cis- and trans-octahydrobenzo[f]quinoline and trans-octahydrobenzo[g]quinoline

Publisher Website
Google Scholar
Abstract
The so-called .beta. conformer of dopamine has been proposed to be involved in agonist-receptor interactions at several sites in the dopaminergic nervous system. To evaluate this proposal, rigid congeners of the .beta. conformer derived from linearly and angularly annelated octahydrobenzoquinolines were synthesized. Certain N-alkylated trans-angularly annelated systems exhibited unusually potent and highly selective dopamine-like effects in an assay on a cardioaccelerator nerve preparation in the cat, but these compounds were inactive in a variety of assays for CNS effects. These compounds present a clear separation of CNS effects from some potent peripheral effects.