The Role of the Platelet Membrane in Platelet Function: II. 5-Hydroxytryptamine (Serotonin) Uptake
- 1 November 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 60 (5) , 636-643
- https://doi.org/10.1093/ajcp/60.5.636
Abstract
The uptake of 14C-5-hydroxytryptamine (14C-5-HT) by platelets was studied. Alteration of the carbohydrate-rich coating of platelets with enzymes depressed 14C-5-HT uptake. With the exception of neuraminidase, enzymatic treatment also released significant amounts of 14C-5-HT taken up by the platelets before the treatment. The decreased uptake of 14C-5-HT by platelets after treatment with neuraminidase could be prevented, at least in part. Ganglioside added after neuraminidase treatment but before incubation with 14C-5-HT partly restored the ability of the platelets to take up 14C-5-HT. Treatment of platelets with sodium metaperiodate enhanced markedly the uptake of 14C-5-HT.Keywords
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