Metabolic Hypotheses in Schizophrenia

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Abstract
The report by Freeman et al. in this issue (page 491) of another case of psychosis and mental retardation in homocystinuria raises a number of interesting points about metabolic research in psychiatry. There has been repeated discussion in recent decades of the possibility that some features of the idiopathic psychoses could be attributed to the abnormal accumulation in the brain of toxic chemical substances, including methylated amines. This methylation hypothesis for schizophrenia1 was initially based on the structural similarity of some endogenous metabolites to methylated hallucinogenic alkaloids such as mescaline and certain N-methylated tryptamines. The idea was given further . . .

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