The Role of Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Modeling in Drug Discovery and Development

This publication has 38 references indexed in Scilit:

• Modelling and PBPK Simulation in Drug Discovery
  The AAPS Journal, 2009
• Accelerating Drug Development Using Biomarkers: A Case Study with Sitagliptin, A Novel DPP4 Inhibitor for Type 2 Diabetes
  The AAPS Journal, 2008
• The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials
  British Journal of Cancer, 2007
• Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling: Biophase Distribution, Receptor Theory, and Dynamical Systems Analysis
  Annual Review of Pharmacology and Toxicology, 2007
• Compressing drug development timelines in oncology using phase '0' trials
  Nature Reviews Cancer, 2007
• A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics
  Clinical Pharmacokinetics, 2006
• Nonlinear dynamics in Clinical Pharmacology: the paradigm of cortisol secretion and suppression
  British Journal of Clinical Pharmacology, 2002
• Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
  Clinical Pharmacology & Therapeutics, 2001
• Utilisation of Pharmacokinetic- Pharmacodynamic Modelling and Simulation in Regulatory Decision-Making
  Clinical Pharmacokinetics, 2001
• Physiological Parameter Values for Physiologically Based Pharmacokinetic Models
  Toxicology and Industrial Health, 1997