Nodal signalling in vertebrate development
Top Cited Papers
- 1 January 2000
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 403 (6768) , 385-389
- https://doi.org/10.1038/35000126
Abstract
Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan. Recent work suggests that a signalling pathway centering on Nodal, a transforming growth factor β-related signal, is responsible for many of the events that configure the vertebrate embryo. The activity of Nodal signals is regulated extracellularly by EGF-CFC cofactors and antagonists of the Lefty and Cerberus families of proteins, allowing precise control of mesoderm and endoderm formation, the positioning of the anterior–posterior axis, neural patterning and left–right axis specification.Keywords
This publication has 70 references indexed in Scilit:
- Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate GastrulationMolecular Cell, 1999
- derrière: a TGF-β family member required for posterior development in XenopusDevelopment, 1999
- FORMATION AND FUNCTION OF SPEMANN'S ORGANIZERAnnual Review of Cell and Developmental Biology, 1997
- Activin signalling has a necessary function in Xenopus early developmentCurrent Biology, 1997
- Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.Genes & Development, 1995
- A nodal-related gene defines a physical and functional domain within the Spemann organizerCell, 1995
- Functional analysis of activins during mammalian developmentNature, 1995
- Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP‐2 and BMP‐4Developmental Genetics, 1995
- Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulationNature, 1993
- A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryosNature, 1992