Abstract
Cat kidneys perfused from a heart-lung circuit with blood taken from donor animals after exclusion of the head from the circulation excrete more water and a greater percentage of the filtered sodium than do kidneys similarly perfused with blood from intact donor animals. Whereas vasopressin corrects t his excessive water loss, it does not reduce the accompanying sodium loss. Oxytocin, and 1: 1 mixtures of vasopressin and oxytocin have similarly failed to prevent this sodium leak.

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