Loss of chromosome 3 alleles and multiplication of chromosome 8 alleles in uveal melanoma
- 1 April 1992
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 4 (3) , 217-221
- https://doi.org/10.1002/gcc.2870040305
Abstract
Uveal melanoma is the most frequent primary intraocular tumor. The etiology is unknown. Using neutral DNA polymorphisms on chromosomes 2, 3, and 8, we have detected loss of chromosome 3 alleles in 8 of 13 tumors and multiplication of chromosome 8 alleles in 6 of 11 tumors. No anomalies at a locus on chromosome 2 were found in 10 of 10 tumors. These results confirm and extend previous cytogenetic findings and suggest that a tumor suppressor gene on chromosome 3 and an oncogene on chromosome 8 may be involved in the formation or progression of this tumor.Keywords
This publication has 17 references indexed in Scilit:
- Structure and function of telomeresNature, 1991
- Telomere reduction in human colorectal carcinoma and with ageingNature, 1990
- Monosomy 3 and isochromosome 8q in a uveal melanomaCancer Genetics and Cytogenetics, 1990
- Four RFLPs at the D8S42 locusNucleic Acids Research, 1990
- The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory elementCell, 1989
- Rapid typing of tandemly repeated hypervariable loci by the polymerase chain reaction: application to the apolipoprotein B 3' hypervariable region.Proceedings of the National Academy of Sciences, 1989
- Trisomy 6p in an ocular melanomaCancer Genetics and Cytogenetics, 1988
- Die prognostische Relevanz histopathologischer Parameter beim malignen Melanom der Aderhaut unter Anwendung der pTNM-KlassifikationKlinische Monatsblätter für Augenheilkunde, 1988
- Detection of submicroscopic deletions and a DNA polymorphism at the retinoblastoma locusHuman Genetics, 1987
- Expression of recessive alleles by chromosomal mechanisms in retinoblastomaNature, 1983