Tamoxifen in Malignant Melanoma

Abstract
To the Editor: In the issue of July 5, Lerner et al. reported a possible adverse effect of oral contraceptives on the course of malignant melanoma. However, estrogens have been used to treat patients with malignant melanoma.1 We have treated 26 patients with advanced malignant melanoma with the antiestrogen tamoxifen, 20 to 40 mg per day. There were five women (four postmenopausal and one premenopausal) and 21 men. Five patients had received previous immunotherapy (BCG vaccine) and three had received previous chemotherapy. The dominant site of disease was soft tissue in 15 patients, viscera in nine patients, and bone and . . .

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