T Cell Production Slowed, Not Exhausted?

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Abstract
Does the AIDS virus cause the disease9s signature symptom--the progressive loss of CD4 T lymphocytes, the primary immune cell targeted by HIV--by destroying T cells so quickly and efficiently that the immune system exhausts itself trying to replace them, or does it disrupt the immune system9s ability to produce T cells in the first place? In the January issue of Nature Medicine, a team reports results obtained by using a new technique that for the first time provides a direct measure of how many new cells are produced over a given time period. The findings, the team says, support the notion that HIV9s most important and insidious talent is to interfere with T cell production.

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