Modification in Growth of Transplantable Rat Tumors Exposed to Friend Virus

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Abstract
Three transplantable tumor cell lines (WST-5 sarcoma, Takeda sarcoma, and DLT lung carcinoma) exposed to Friend virus had a low success rate of transplantation into susceptible rats, and even when transplantation was accomplished, the tumor cells regressed spontaneously. Of the 3 lines, the rapid growth rate of the Takeda sarcoma resulted in early death of the host, and the effect of infection with Friend virus could not always be discerned. When the host was previously immunized with Friend virus, however, the effect became as clearly discernible as in the two other lines. This was not because the rat tumor cell showed the cytopathic effect of Friend virus nor because of the environmental change of the host brought about by Friend virus inoculation, but was probably because of the production of Friend virus-related antigen on the surface of the tumor cell resulting from Friend virus infection. The significance of using a noncytopathic virus, which altered the surface of tumor cells and which was too weakly infectious to the host to modify the growth of tumor, is discussed.

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