THE EFFECT OF DOCA AND 9α‐FLUDROCORTISONE ON RENAL RENIN CONTENT AND PRODUCTION
- 1 March 1987
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 14 (3) , 259-262
- https://doi.org/10.1111/j.1440-1681.1987.tb00386.x
Abstract
1. DOCA and 9 alpha-fludrocortisone were given to rats. 2. Plasma renin fell rapidly with both treatments. 3. Renal renin fell slowly to a low level. 4. Renal renin fell to a lower level with DOCA than with 9 alpha-fludrocortisone. 5. When DOCA and 9 alpha-fludrocortisone were stopped plasma renin levels rose rapidly and the renal renin levels increased. 6. The data suggest that synthesis is altered rapidly but it takes a prolonged time for the kidney to become depleted of renin due to the high tissue stores and the associated inhibition of release.Keywords
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