Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy
- 21 May 2008
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 37 (7) , 1320-1329
- https://doi.org/10.1039/b702780j
Abstract
A variety of natural products modulate critical biological processes in the microorganisms that produce them. Thus, inhibition of the corresponding natural product biosynthesis pathways represents a promising avenue to develop novel antibiotics. In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy.Keywords
This publication has 58 references indexed in Scilit:
- Mycobacterial Phenolic Glycolipid Virulence Factor Biosynthesis: Mechanism and Small-Molecule Inhibition of Polyketide Chain InitiationChemistry & Biology, 2008
- 5‘-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the MycobactinsJournal of Medicinal Chemistry, 2007
- Exploiting Ligand Conformation in Selective Inhibition of Non-Ribosomal Peptide Synthetase Amino Acid Adenylation with Designed Macrocyclic Small MoleculesJournal of the American Chemical Society, 2007
- A Mechanism-Based Aryl Carrier Protein/Thiolation Domain Affinity ProbeJournal of the American Chemical Society, 2007
- Antitubercular Nucleosides That Inhibit Siderophore Biosynthesis: SAR of the Glycosyl DomainJournal of Medicinal Chemistry, 2006
- The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2Proceedings of the National Academy of Sciences, 2006
- Design, Synthesis, and Biological Evaluation of β-Ketosulfonamide Adenylation Inhibitors as Potential Antitubercular AgentsOrganic Letters, 2006
- The Structure of MbtI from Mycobacterium tuberculosis , the First Enzyme in the Biosynthesis of the Siderophore Mycobactin, Reveals It To Be a Salicylate SynthaseJournal of Bacteriology, 2006
- Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and MechanismsChemical Reviews, 2006
- Natural Products as Sources of New Drugs over the Period 1981−2002Journal of Natural Products, 2003