Immunization of LDL Receptor–Deficient Mice With Homologous Malondialdehyde-Modified and Native LDL Reduces Progression of Atherosclerosis by Mechanisms Other Than Induction of High Titers of Antibodies to Oxidative Neoepitopes
- 1 December 1998
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 18 (12) , 1972-1982
- https://doi.org/10.1161/01.atv.18.12.1972
Abstract
—We and others previously showed that immunization of rabbits with different forms of oxidized low density lipoprotein (LDL) significantly reduced atherogenesis. We now investigated the eff...Keywords
This publication has 48 references indexed in Scilit:
- INDUCTION OF TH1 AND TH2 CD4+T CELL RESPONSES:The Alternative ApproachesAnnual Review of Immunology, 1997
- Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbitsAtherosclerosis, 1996
- Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.Journal of Clinical Investigation, 1996
- Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity.Journal of Clinical Investigation, 1995
- Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet.Journal of Clinical Investigation, 1994
- Serum antibodies to oxidised low-density lipoprotein in pre-eclampsia and coronary heart diseaseThe Lancet, 1994
- Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.Journal of Clinical Investigation, 1993
- Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydesFree Radical Biology & Medicine, 1991
- Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.Journal of Clinical Investigation, 1989
- Beyond CholesterolNew England Journal of Medicine, 1989