Correlation of Plasma Phenformin Concentration with Metabolic Effects in Normal Subjects
- 1 February 1980
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 58 (2) , 153-155
- https://doi.org/10.1042/cs0580153
Abstract
1. Circulating concentrations of intermediary metabolites have been measured after administration of 50 mg of phenformin to normal subjects. 2. Phenformin caused a significant increase in blood lactate, alanine and the lactate/pyruvate ratio but did not affect blood glucose or serum insulin concentrations. 3. There was a significant correlation between the increase in blood lactate concentration after phenformin and the plasma concentration of the drug.Keywords
This publication has 1 reference indexed in Scilit:
- A kinetic spectrophotometric assay for rapid determination of acetoacetate in blood.Clinical Chemistry, 1977