Effect of Levamisole on Morphology, Bactericidal Activity, and Metabolism of Human Neutrophils in Vitro

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Abstract
The anthelmintic agent, levamisole hydrochloride, was shown to alter function of monocytes and macrophages and to increase random locomotion and chemotaxis of neutrophils. The present investigation extends the knowledge about this potentially clinically useful agent. In the optimal range of doses used in prior studies, levamisole produces vacuole formation but does not alter bactericidal activity, O2 consumption, [1-14C]glucose oxidation, nitroblue tetrazolium reduction or chemiluminescence of neutrophils from normal subjects. Levamisole was demonstrated to have no effect on neutrophils from patients with chronic granulomatous disease. The major effects of levamisole on neutrophil function may relate to its ability to improve random locomotion and chemotaxis.

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