Assignment of the human and mouse prion protein genes to homologous chromosomes.
- 1 October 1986
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 83 (19) , 7358-7362
- https://doi.org/10.1073/pnas.83.19.7358
Abstract
Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles. The PrP gene was assigned to human chromosome 20 and the corresponding mouse chromosome 2 using somatic cell hybrids. In situ hybridization studies mapped the human PrP gene to band 20p12.fwdarw.pter. Our results should lead to studies of genetic loci syntenic with with PrP gene, which may play a role in the pathogenesis of prion diseases or other degenerative neurologic disorders.This publication has 38 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Scrapie and cellular PrP isoforms are encoded by the same chromosomal geneCell, 1986
- Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brainNature, 1985
- A cellular gene encodes scrapie PrP 27-30 proteinCell, 1985
- Purification and structural studies of a major scrapie prion proteinCell, 1984
- Novel Proteinaceous Infectious Particles Cause ScrapieScience, 1982
- Creutzfeldt‐Jakob disease: Patterns of worldwide occurrence and the significance of familial and sporadic clusteringAnnals of Neurology, 1979
- Ouabain as a selective agent in the isolation of somatic cell hybridsCytogenetic and Genome Research, 1975
- Assignment of a Gene for Adenosine Deaminase to Human Chromosome 20Human Heredity, 1974
- Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed RecombinantsScience, 1964