Sterilizing Activity of Bis(1-aziridinyl)phosphine Oxides and Sulfides in Male House Flies13

Abstract
When sterilizing doses SD50 and SD95 of 10 substituted bis (1-aziridinyl) phosphine oxides and 10 substituted bis (1-aziridinyl) phosphine sulfides were determined in male Musca domestica L., the alkylamino-substituted compounds were the most effective sterilants, followed by the alkylthio-, alkoxy-, and alkyl-substituted analogues. Within each homologous series, activity decreased with increasing size of the alkyl group. Only minor differences in activity were found between analogous phosphine oxides and sulfides.

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