Direct HPLC Resolution of Racemic Nomifensine Hydrogen Maleate Using a Chiral Beta-Cyclodextrin-Bonded Stationary Phase
- 1 May 1988
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 11 (7) , 1485-1493
- https://doi.org/10.1080/01483918808067188
Abstract
A direct liquid chromatographic method was developed for the optimization of separation of racemic S, R-nomifensine hydrogen maleate, a psychotropic drug, this was achieved without any derivatization, using a β-cyclodextrin-bonded phase column. A separation factor of 1.46 and resolution of 4.30 were obtained for the enantiomers of nomifensine hydrogen maleate. The effect of pH, temperature and methanol content in mobile phase on retention and enantioselectivity of nomifensine hydrogen maleate was also demonstrated.This publication has 12 references indexed in Scilit:
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