Association of White Matter Hyperintensity Volume With Decreased Cognitive Functioning
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Open Access
- 1 February 2006
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 63 (2) , 246-250
- https://doi.org/10.1001/archneur.63.2.246
Abstract
Imaging research finds that white matter hyperintensities (WMHs) occur in individuals presumed free of neurologic disease,1,2 as well as those with stroke3,4 and dementia.5-7 The cause of WMH, however, remains a matter of debate; it may be associated with ischemic disease, as supported by positive associations with cerebrovascular risk factors,8-12 or representative of nonspecific brain changes that reflect a variety of processes including normal aging, cerebrovascular disease, and Alzheimer disease.13Keywords
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