Pharmacokinetics of Ketoprofen in Patients with Chronic Renal Failure
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 10 (3) , 189-192
- https://doi.org/10.3109/03009748109095297
Abstract
The pharmacokinetics of ketoprofen were studied in 7 volunteers and in 5 patients suffering from varying degrees of renal insufficiency. All the subjects received a single oral dose (50 mg) of ketoprofen. Plasma concentrations were measured up to 24 hours after administration and urinary excretion for 2 days. Ketoprofen concentrations were determined by mass-fragmentography with a minimum level of detection of 0.02 mg/1. As expected, a reduction of the [51Cr]EDTA clearance was correlated with an increase in the elimination half-life of ketoprofen. The urinary excretion corresponded to results reported by other groups.This publication has 1 reference indexed in Scilit:
- [51Cr] EDTA plasma clearance and endogenous creatinine clearance in advanced renal insufficiencyScandinavian Journal of Clinical and Laboratory Investigation, 1978