Drosophila melanogaster (Diptera: Drosophilidae): A Model Insect for Insecticide Resistance Studies

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Abstract
Although the biochemical basis of insect resistance to many pesticides is understood reasonably well, little is known of the genetic mechanisms underlying the evolution of resistance. A major reason for this shortcoming is difficulty with genetic manipulations of most insect pests. The fruit fly, Drosophila melanogaster (Meigen), is uniquely suited as a model insect to investigate the classical, population, and molecular genetics of resistance evolution. The advantages and disadvantages of D. melanogaster for this work are discussed. Cloned sequences from D. melanogaster resistant genes can be used to identify and study homologous genes in pest species.

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