Innate immunity and inflammation – two facets of the same anti-infectious reaction
- 4 February 2009
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 156 (2) , 194-198
- https://doi.org/10.1111/j.1365-2249.2009.03893.x
Abstract
Summary: Innate immunity is the host's first line of defence against infection. In this review, we present the innate immune response implicated in three examples of pulmonary infection of viral, fungal and bacterial origin. We show that this defence against infection can be a double-edged sword. Thus, the same cells, molecules and mechanisms involved in this protective process can also be involved in deleterious inflammation. A delicate balance between immunity and inflammation is therefore required, making it possible to fight pathogens effectively while limiting inflammation that might be damaging to the host.Keywords
This publication has 41 references indexed in Scilit:
- Aspergillus fumigatus-induced Interleukin-8 Synthesis by Respiratory Epithelial Cells Is Controlled by the Phosphatidylinositol 3-Kinase, p38 MAPK, and ERK1/2 Pathways and Not by the Toll-like Receptor-MyD88 PathwayJournal of Biological Chemistry, 2008
- Edema Toxin Impairs Anthracidal Phospholipase A2 Expression by Alveolar MacrophagesPLoS Pathogens, 2007
- Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute PneumoniaPLoS Pathogens, 2006
- Pathogen Recognition and Innate ImmunityCell, 2006
- Innate Immunity in the LungsProceedings of the American Thoracic Society, 2005
- Inflammation – A New Therapeutic Target in PneumoniaRespiration, 2005
- Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A VirusJournal of Biological Chemistry, 2005
- Septic shockPublished by Elsevier ,2005
- Host Defense and Bacterial PneumoniaSeminars in Respiratory and Critical Care Medicine, 2004
- AnthraxAnnual Review of Microbiology, 2001