Increased calmodulin synthesis in the pre‐replicative phase of rat liver regeneration

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Abstract
A cytosolic calmodulin wave has been described in the pre‐replicative phase of rat liver regeneration. Here we demonstrate that this calmodulin increase is reduced by injection of cycloheximide (translation inhibitor) and actinomycin D (transcription inhibitor). In addition, we found that calmodulin mRNA levels are increased during the early pre‐replicative period of liver regeneration, and this increase is affected by actinomycin D. Together, these results strongly indicate that the calmodulin wave observed in the pre‐replicative phase of liver regeneration is due to de novo synthesis of this protein.