A plausible two-state model for cytochrome c oxidase.
- 1 November 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (11) , 7115-7118
- https://doi.org/10.1073/pnas.78.11.7115
Abstract
The catalytic properties of pulsed and resting cytochrome c oxidase (ferrocytochrome c: oxygen oxidoreductase, EC 1.9.3.1), expressed in terms of a minimal kinetic scheme and simulated by numerical computations, were successfully described. A two-state model, in which the relative amounts of the enzyme present in each conformation are regulated by the rates of electron flux and O2 binding on one side and the interconversion rates on the other, accounts for the activation of cytochrome c oxidase during turnover.This publication has 28 references indexed in Scilit:
- Studies on partially reduced mammalian cytochrome oxidase reactions with ferrocytochrome cBiochemical Journal, 1976
- Kinetic studies on the binding of cyanide to oxygenated cytochrome c oxidaseBiochemical Journal, 1976
- Functional intermediates in the reaction of membrane-bound cytochrome oxidase with oxygen.Journal of Biological Chemistry, 1975
- The turning wheel: a study in steady states.Proceedings of the National Academy of Sciences, 1975
- Kinetic studies on the reaction between cytochrome c oxidase and ferrocytochrome cBiochemical Journal, 1975
- Studies on partially reduced mammalian cytochrome oxidase. Reactions with carbon monoxide and oxygenBiochemical Journal, 1974
- Heme—Heme interaction in cytochrome c oxidase: The cooperativity of the hemes of cytochrome c oxidase as evidenced in the reaction with COArchives of Biochemistry and Biophysics, 1974
- Biochemical and biophysical studies on cytochrome aa3. VII. The effect of cytochrome c on the oxidation-reduction potential of isolated cytochrome aa3Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1972
- The Reaction of Reduced Cytochrome c Oxidase with OxygenJournal of Biological Chemistry, 1967
- On the nature of allosteric transitions: A plausible modelJournal of Molecular Biology, 1965