THE RELATIONSHIP OF SERUM GAMMA-GLOBULIN CONCENTRATION TO MALARIA AND SICKLING
Open Access
- 1 March 1960
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 13 (2) , 118-123
- https://doi.org/10.1136/jcp.13.2.118
Abstract
The serum protein patterns of groups of Nigerians including 98 children partially protected by “daraprim” against malaria, and 113 unprotected children, have been studied. The protected children have a significantly lower concentration of serum γ globulin than the unprotected children from the age of 12 months onwards. In children, sicklers have a significantly higher serum γ globulin than non-sicklers. It is suggested that sickling protects against malaria by enhancing the antibody response against the malaria parasite.Keywords
This publication has 21 references indexed in Scilit:
- Further observations on sickling and malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1959
- Serum protein changes induced by plasmodium berghei infection in rats and plasmodium knowlesi infection in monkeysTransactions of the Royal Society of Tropical Medicine and Hygiene, 1957
- The Serum Proteins of Healthy Adult NigeriansJournal of Clinical Pathology, 1957
- The serum protein pattern of West Africans in BritainTransactions of the Royal Society of Tropical Medicine and Hygiene, 1957
- RACIAL VARIATION IN SERUM GLOBULINSThe Lancet Healthy Longevity, 1957
- Effects of Heavy and Repeated Malarial Infections on Gambian Infants and ChildrenBMJ, 1956
- Serum Protein Concentrations in the North American NegroidScience, 1956
- Distribution of parasites in the red cells of sickle-cell trait carriers infected with Plasmodium falciparumTransactions of the Royal Society of Tropical Medicine and Hygiene, 1956
- Protection Afforded by Sickle-cell Trait Against Subtertian Malarial InfectionBMJ, 1954
- MICRO-ELECTROPHORESIS OF PROTEIN ON FILTER-PAPER*1The Lancet, 1951