Gated 99Tcm-cm-MIBI myocardial function imaging

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Abstract
The introduction of the 99Tcm isonitrile perfusion agents has provided improved myocardial image quality with conventional imaging equipment allowing improved edge definition on gating. We evaluated left ventricular wall motion in 46 patients using gated 99Tcm-2-methoxy-2-methyl-isopropyl-1 -isonitrile (MIBI) scintigraphy. Using a method of myocardial profiles in four axes, global and regional fractional shortening (FS) were assessed. A good correlation was found between FS in the left anterior oblique (LAO) 40° projection and ejection fraction (EF) on gated radionuclide ventriculography (r = 0.81, P <0.001). This was improved by using FS in two planes, LAO 40° and anterior (r = 0.88, P < 0.001). There was also a good correlation between FS in two planes and EF on cine-angiography (r = 0.72, P <0.001). There was good intra- and interobserver agreement with the studies. Assessment of myocardial function using gated MIBI imaging and myocardial profiles provides useful additional information to the perfusion scan, thus enhancing the diagnostic usefulness of the agent.

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