Depressed Splenic T Lymphocyte Numbers and Thymocyte Migratory Patterns in Murine Malaria

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Abstract
A progressive depression in the splenic T [thymus-derived]-cell population occurs in Plasmodium berghei-infected mice; T cell migration is abnormal. Since the thymus and lymph nodes involute in P. berghei-infected mice, T cell pool may be depleted in the infected mouse. The decreased ability of transplanted thymus cells to seed into the infected spleen and the decreased T cell population may indicate that infected mice have an environment hostile to T cell viability.