Revised concepts of atherogenesis: A review

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Abstract
All of the presently recommended interventions for lowering major risk factors in individuals and in populations can be expected to reduce the incidence of endothelial injury and at least slow the rate of plaque development. A similar but more direct approach to prevention might be to search for agents which will protect the endothelium against low grade injury. Failing this, it might be feasible to diminish the response of subendothelial intimal tissue to endothelial damage. This might be achieved by inhibiting platelet function with drugs such as dipyridamole or aspirin or by inhibiting the proliferative and synthetic responses within the intima with agents which are specific and nontoxic. Urgent priority should be given to the development of such agents and to basic research which will further knowledge of the cellular and molecular causes of the disease.

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