Clinical Experiences with Guanethidine in Ambulatory Hypertensive Subjects

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Abstract
THE reports of numerous investigators1 2 3 4 5 6 7 8 9 10 11 have demonstrated guanethidine to be a potent hypotensive agent. The purpose of this paper is to describe its clinical effects in a group of 28 ambulatory hypertensive subjects. These patients also had independent trials with thiazide drugs to appraise the relative merits of the two types of compounds.PharmacologyGuanethidine is a synthetic compound (2-[octahydro-1-azocinyl]-ethylguanidine sulfate). Its hypotensive effect is initiated by inhibition of sympathetic activity without concomitant parasympathetic blockade. Its hypotensive action is thought to be located at the junction of the sympathetic nerve endings and the receptors in the arteriolar smooth muscle, where . . .