Relationship Between Amygdala Responses to Masked Faces and Mood State and Treatment in Major Depressive Disorder
Top Cited Papers
Open Access
- 1 November 2010
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 67 (11) , 1128-1138
- https://doi.org/10.1001/archgenpsychiatry.2010.144
Abstract
A mood-congruent processing bias toward negatively valenced emotional stimuli is a consistent pathophysiological feature of major depressive disorder (MDD). This bias is evident in behavioral measures that evaluate memory and attention1-4 as well as in neurophysiological indexes.5-10 For example, neurophysiological responses to explicitly presented sad faces are exaggerated in the amygdala in depressed patients compared with healthy controls (HCs),11 and this abnormality normalizes after antidepressant drug treatment.12Keywords
This publication has 45 references indexed in Scilit:
- The NimStim set of facial expressions: Judgments from untrained research participantsPublished by Elsevier ,2009
- Neural basis of abnormal response to negative feedback in unmedicated mood disordersNeuroImage, 2008
- Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depressionBrain Structure and Function, 2008
- Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performancePsychological Medicine, 2003
- Mood Congruence and Depressive Deficits in Memory: A Forced-recall AnalysisMemory, 1999
- Evidence for attention to threatening stimuli in depressionBehaviour Research and Therapy, 1996
- Attentional bias in anxiety and depression: The role of awarenessBritish Journal of Clinical Psychology, 1995
- Masking the face: Recognition of emotional facial expressions as a function of the parameters of backward maskingScandinavian Journal of Psychology, 1993
- Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.Behavioral Neuroscience, 1992
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960