Abstract
Thirty patients undergoing surgery were given tubocurarine chloride on a body-weight basis and were monitored electromyographic-ally. Reversal of the neuromuscular blockage was then accomplished with incremental doses of neostigmine methylsulfate. A previous study in which the tubocurarine-induced neuromuscular blockage was reversed with neostigmine administered from 3 to 90 min. after the tubocurarine was reviewed. No precise relationship between a dose of tubocurarine, based on body weight and the final degree of paralysis was observed. The optimum dose of neostigmine required to establish the complete reversal of severe neuromuscular blockade due to tubocurarine is almost 4 to 5 mg. This reversal can be achieved even when the time interval between the relaxant and antidote is only a few min.