In vivo AND in vitro EFFECTS OF ENDOTOXIN ON PROSTAGLANDIN RELEASE FROM RAT LUNG

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Abstract
1 The release of prostaglandins (PGE2, PGF2α, PGI2) and thromboxane A2 (T×A2) from rat lung exposed to E. coli endotoxin, in vivo ox in vitro has been studied. 2 Lung strips of endotoxin-treated rats demonstrated a preferential increase of T×A2 and PGF2α and a decrease in the ratio PGI2/T×A2. 3 These data suggest that changes in the proportions of arachidonic acid metabolites might play a role in the pulmonary pathophysiology during endotoxin shock. 4 Incubation of lung strips with endotoxin in vitro failed to stimulate prostaglandin release; paradoxically, it suppressed both the spontaneous and the ionophore-induced prostaglandin release. 5 These findings suggest that the increase in prostaglandin release by the lung following endotoxin administration in vivo is probably mediated by factor(s) generated in endotoxaemia and is not due to a direct action of endotoxin on the lung tissue.