Genetic polymorphism of vitamin B12 binding (R) proteins of human saliva detected by isoelectric focusing
- 1 October 1979
- journal article
- research article
- Published by Springer Nature in Biochemical Genetics
- Vol. 17 (9-10) , 909-920
- https://doi.org/10.1007/bf00504312
Abstract
Genetic polymorphism of the vitamin B12 binding (R) proteins of parotid saliva is determined by autosomal inheritance of codominant alleles. This hypothesis is supported by studies in 43 families including 152 children. For randomly collected salivas from 143 whites, 104 blacks, and 75 Chinese, gene frequencies are as follows: for whites, Rs 1=0.88, Rs 2=0.12; for blacks, Rs 1=0.94, Rs 2=0.06; for Chinese, Rs 1=1.00. This genetic marker is also shared by R proteins of milk, tears, and leukocytes. In the Rs 1–2 salivary type there is less labeling of the protein products of Rs 2 v. Rs 1 with 57Co B12 as assessed by the intensity of the bands on the autoradiogram. There is no evidence for close linkage (θRs and TC II (transcobalamin II) or between Rs and salivary protein locus Pr, Db, Gl, or Ps.Keywords
This publication has 20 references indexed in Scilit:
- Genetic polymorphism of the major parotid salivary glycoprotein (Gl) with linkage to the genes for Pr, Db, and PaBiochemical Genetics, 1979
- Effect of Proteolytic Enzymes on the Binding of Cobalamin to R Protein and Intrinsic FactorJournal of Clinical Investigation, 1978
- Vitamin B12‐Binding Proteins of R‐Type, CobalophilinScandinavian Journal of Haematology, 1975
- Clinical Chemistry: Characterization of R-Type Vitamin B12-Binding Proteins by Isoelectric FocusingScandinavian Journal of Clinical and Laboratory Investigation, 1975
- Characterization of R‐Type Vitamin B12‐Binding Proteins by Isoelectric FocusingScandinavian Journal of Haematology, 1974
- Amniotic fluid vitamin B12-binding proteinBiochimica et Biophysica Acta (BBA) - Protein Structure, 1974
- Gradients for isoelectric focussing at low pHBiochimica et Biophysica Acta (BBA) - General Subjects, 1972
- The vitamin B12-binding protein in human saliva isolation, characterization and comparison with the unpurified proteinBiochimica et Biophysica Acta (BBA) - Protein Structure, 1972
- Deficiency of Vitamin B12-Binding Alpha Globulin in Two BrothersBlood, 1969
- Immunoelectrophoresis of human gastric juiceClinica Chimica Acta; International Journal of Clinical Chemistry, 1963