Pattern of Response of Intact Drosophila to Known Teratogens

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Abstract
Drosophila, as the test organism, was used to assess 17 chemicals. The teratogenic potential of 15 of these chemicals is well established from animal studies or human epidemiology. The test involves examination of adult flies following treatment during larval stages of development. Flies are examined for abnormal external morphology. The incidence of abnormalities in treated and control populations is compared using the Chi-square test. All 17 chemicals were active to varying degrees in the test system. Most chemicals produced a unique response yielding individual patterns of abnormalities. These results suggest that Drosophila may have the potential to become a valuable teratogen screen, but further, more rigorous examination–particularly with nonteratogens–is required.