Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
Top Cited Papers
- 1 September 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 289 (5484) , 1567-1569
- https://doi.org/10.1126/science.289.5484.1567
Abstract
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems ofCaenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.Keywords
This publication has 17 references indexed in Scilit:
- Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegansPublished by Elsevier ,2003
- The p66shc adaptor protein controls oxidative stress response and life span in mammalsNature, 1999
- FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster FliesMolecular and Cellular Biology, 1999
- Extension of Drosophila lifespan by overexpression of human SOD1 in motorneuronsNature Genetics, 1998
- Prevention and Suppression of Autoimmune Encephalomyelitis by EUK-8, a Synthetic Catalytic Scavenger of Oxygen-Reactive MetabolitesCellular Immunology, 1997
- beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger.Proceedings of the National Academy of Sciences, 1996
- Aging, energy, and oxidative stress in neurodegenerative diseasesAnnals of Neurology, 1995
- Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogasterScience, 1994
- Aging and resistance to oxidative damage in Caenorhabditis elegans.Proceedings of the National Academy of Sciences, 1993
- Oxidative stress and ageing in Caenorhabditis elegansBiochemical Journal, 1993