COMPARISON OF IMMUNE-RESPONSES INDUCED BY RAT RT-1 ANTIGENS PRESENTED AS INSERTS INTO LIPOSOMES, AS PROTEIN MICELLES AND AS INTACT-CELLS
- 1 January 1984
- journal article
- research article
- Vol. 53 (1) , 69-78
Abstract
Partially purified rat transplantation antigens (RT-1) were inserted into liposomes composed of various types of lipids and used for immunization. The immune responses induced by the liposomes were compared with responses induced by RT-1 as protein micelles, alone or emulsified in Freund''s incomplete adjuvant, or intact cells. Liposomes gave generally a higher humoral response than protein micelles. Each type of RT-1 immunization gave a particular pattern of specific Ig (sub)class responses. Freund''s incomplete adjuvant was not only lacking in potentiating effect on low protein dose immunization but had a significant inhibitory effect. Besides intact cells only distearoyl-phosphatidylcholine liposomes had the potential to induce a cell-mediated cytotoxic response.This publication has 12 references indexed in Scilit:
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