Visual evoked potentials in patients with neuropathy and macroglobulinemia

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Abstract
Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M‐proteins reacted with myelin‐associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M‐protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M‐protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti‐MAG M‐proteins and may be due to the binding of M‐proteins to central nervous system myelin.