Studies on Peptides. XV. Synthesis of Prolyltyrosylarginylmethionine, the Tetrapeptide situated within the Amino Acid Sequences of Monkey and Human β-Melanocyte-stimulating Hormones.
- 1 January 1967
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 15 (12) , 1922-1928
- https://doi.org/10.1248/cpb.15.1922
Abstract
Arginylmethionine was prepared by three different methods, one from Nα-benzyloxycarbonyl-NG-tosylarginylmethionine with sodium in liquid ammonia and others, from Nα-benzyloxycarbonyl-NG-nitroarginylmethionine by treatment with hydrogen fluoride, and from Nα-t-butoxycarbonyl-NG-nitroarginylmethionine by treatment with stannous chloride in 80% formic acid. Arginylmethionine was coupled with Nα-t-butoxycarbonylprolyltyrosine via the azide method and the resulting peptide was treated with trifluoroacetic acid to give prolyltyrosylarginylmethionine, the tetrapeptide situated within the structures of monkey and human β-melanocyte-stimulating hormones.Keywords
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