ANOREXIA AND WEIGHT-LOSS IN PORTACAVAL-SHUNTED PIG

  • 1 January 1976
    • journal article
    • research article
    • Vol. 80  (5) , 569-574
Abstract
The pig shows a marked response to end-to-side portacaval shunt. Survival is short and levels of alkaline phosphatase and cholesterol fall. In pair-fed, sham-operated pigs, survival was short and levels of alkaline phosphatase and cholesterol also fell. Sham-operated animals fed normally did not show this response. Reduced appetite was recorded in many experimental animals after portacaval shunt, but the cause remains to be elucidated. Encephalopathy, bacteremia, peptic ulceration or hormonal imbalance could be implicated. Similar alteration in appetite and weight loss were not observed in children who were treated by portacaval shunt for glycogen storage disease or hypercholesterolemia; the underlying metabolic disorder or the species difference may be a contributory cause.

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